FASN-IN-4 (tosylate)

FASN-IN-4 tosylate is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29) [1]. FASN-IN-4 tosylate also inhibits SARS-CoV-2 with an EC50 of 18.6 nM[2].

Product Specifications

CAS Number

[2095432-57-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Fatty Acid Synthase (FASN) ; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/FAS-IN-1-Tosylate.html

Concentration

10mM

Purity

98.55

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

OS(C1=CC=C(C)C=C1)(=O)=O.O=C2COC3(CCN(S(=O)(C4=CC=C(C5=CC=C6C=CC=NC6=C5)C=C4)=O)CC3)CN2C7CC7

Molecular Formula

C33H35N3O7S2

Molecular Weight

649.78

Precautions

H302, H315, H319, H335

References & Citations

[1]Nicholas D. Adams, et al. Fatty acid synthase inhibitors. WO2012064642A1.|[2]Junjun Chu, et al. Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nat Metab. 2021 Nov;3 (11) :1466-1475.