D[Cha4]-AVP (TFA)
D[Cha4]-AVP TFA is a potent and selective vasopressin (AVP) V1b receptor agonist with a Ki of 1.2 nM for human V1b receptor. d[Cha4]-AVP TFA shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors[1][2].
Product Specifications
UNSPSC
12352209
Target
Vasopressin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/d-cha4-avp-tfa.html
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@H](C(N[C@@H](CCCNC(N)=N)C(NCC(N)=O)=O)=O)CCC1)[C@H]2NC([C@H](CC(N)=O)NC([C@H](CC3CCCCC3)NC([C@H](CC4=CC=CC=C4)NC([C@H](CC5=CC=C(O)C=C5)NC(CCSSC2)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F.[x]
Molecular Formula
C50H71N13O11S2.xC2HF3O2
References & Citations
[1]Cristiana Griffante, et al. Selectivity of d[Cha4]AVP and SSR149415 at human vasopressin and oxytocin receptors: evidence that SSR149415 is a mixed vasopressin V1b/oxytocin receptor antagonist. Br J Pharmacol. 2005 Nov;146 (5) :744-51.|[2]Ling Ling Cheng, et al. Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J Med Chem. 2004 Apr 22;47 (9) :2375-88.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
V1b Receptor
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