KYL peptide
Product Specifications
UNSPSC Description
KYL peptide, an antagonistic peptide, selectively targets EphA4 receptor (IC50:4.22 μM, Kd:1.3 μM). KYL peptide binds to the ligand-binding domain of EphA4, effectively alleviates Aβ-induced synaptic dysfunction and synaptic plasticity defects in AD mice. KYL peptide can promote nerve regeneration after injury and modulating immune responses[1][2][3].
Target Antigen
Ephrin Receptor
Type
Peptides
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/kyl-peptide.html
Purity
99.09
Smiles
CC(C)C[C@@H](C(O)=O)NC([C@H](CO)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H]1N(C([C@H](CC2=CNC3=C2C=CC=C3)NC([C@H](CC4=CC=C(O)C=C4)NC([C@H]5N(C([C@H](CC(C)C)NC([C@H](CC6=CC=C(O)C=C6)NC([C@H](CCCCN)N)=O)=O)=O)CCC5)=O)=O)=O)CCC1)=O)=O)=O)=O)=O
Molecular Weight
1465.73
References & Citations
[1]Lamberto I, et, al. Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem J. 2012 Jul 1;445(1):47-56.|[2]Fu AKY, et, al. Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9959-64.|[3]Wu B, et.al. HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery. Chem Biol. 2013 Jan 24;20(1):19-33.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P2264/KYL-peptide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P2264/KYL-peptide-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
676657-00-4
Available Sizes
Curated Selection
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