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KYL peptide

KYL peptide, an antagonistic peptide, selectively targets EphA4 receptor (IC50:4.22 μM, Kd:1.3 μM) . KYL peptide binds to the ligand-binding domain of EphA4, effectively alleviates Aβ-induced synaptic dysfunction and synaptic plasticity defects in AD mice. KYL peptide can promote nerve regeneration after injury and modulating immune responses[1][2][3].

Product Specifications

CAS Number

[676657-00-4]

UNSPSC

12352209

Target

Ephrin Receptor

Type

Peptides

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/kyl-peptide.html

Purity

99.65

Smiles

CC(C)C[C@@H](C(O)=O)NC([C@H](CO)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H]1N(C([C@H](CC2=CNC3=C2C=CC=C3)NC([C@H](CC4=CC=C(O)C=C4)NC([C@H]5N(C([C@H](CC(C)C)NC([C@H](CC6=CC=C(O)C=C6)NC([C@H](CCCCN)N)=O)=O)=O)CCC5)=O)=O)=O)CCC1)=O)=O)=O)=O)=O

Molecular Formula

C74H108N14O17

Molecular Weight

1465.73

References & Citations

[1]Lamberto I, et, al. Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem J. 2012 Jul 1;445 (1) :47-56.|[2]Fu AKY, et, al. Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2014 Jul 8;111 (27) :9959-64.|[3]Wu B, et.al. HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery. Chem Biol. 2013 Jan 24;20 (1) :19-33.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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