Fadrozole (hydrochloride)
Product Specifications
UNSPSC Description
Fadrozole hydrochloride (CGS 16949A) is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM.
Target Antigen
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Fadrozole_hydrochloride.html
Solubility
DMSO : 100 mg/mL (ultrasonic;warming)|H2O : 100 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(C2CCCC3=CN=CN23)C=C1.Cl
Molecular Weight
259.73
References & Citations
[1]Browne LJ, et al. Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. J Med Chem. 1991 Feb;34(2):725-36.|[2]Gunson DE, et al. Prevention of spontaneous tumours in female rats by fadrozole hydrochloride, an aromatase inhibitor. Br J Cancer. 1995 Jul;72(1):72-5.|[3]Morales-Montor J, et al. Inhibition of p-450 aromatase prevents feminisation and induces protection during cysticercosis. Int J Parasitol. 2002 Oct;32(11):1379-87.Dis Model Mech. 2024 Oct 14:dmm.050900.|Ecotoxicol Environ Saf. 2021 Apr 1;212:111991.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14247/Fadrozole-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14247/Fadrozole-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
102676-31-3
Available Sizes
Curated Selection
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