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EGFR-IN-17

EGFR-IN-17 is a potent and selective inhibitor of the epidermal growth factor receptor (IC50 0.0002 μM) to overcome C797S-mediated resistance.

Product Specifications

CAS Number

2817679-31-3

Product Name Alternative

Methophenazine,Methophenazine (diethanesulfonate),R5055,CI-637,U31929

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-17.html

Purity

98.18

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=C(NC2=NC(NC3=C(P(C)(C)=O)C=CC=C3)=C(Cl)C=N2)C=C(C4=CN(C)N=C4)C(N5CCOCC5)=C1

Molecular Formula

C27H31ClN7O3P

Molecular Weight

568.01

References & Citations

[1]Finlay MRV, et al. Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance. J Med Chem. 2021 Sep 23;64 (18) :13704-13718.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

EGFR/ErbB1/HER1

Available Sizes

Frequently Asked Questions

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