EGFR-IN-17
EGFR-IN-17 is a potent and selective inhibitor of the epidermal growth factor receptor (IC50 0.0002 μM) to overcome C797S-mediated resistance.
Product Specifications
CAS Number
[2817679-31-3]
Product Name Alternative
Methophenazine,Methophenazine (diethanesulfonate),R5055,CI-637,U31929
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-17.html
Purity
98.18
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC1=C(NC2=NC(NC3=C(P(C)(C)=O)C=CC=C3)=C(Cl)C=N2)C=C(C4=CN(C)N=C4)C(N5CCOCC5)=C1
Molecular Formula
C27H31ClN7O3P
Molecular Weight
568.01
References & Citations
[1]Finlay MRV, et al. Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance. J Med Chem. 2021 Sep 23;64 (18) :13704-13718.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
Available Sizes
Curated Selection
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