ALK/HDAC-IN-1
ALK/HDAC-IN-1 is a dual inhibitor for ALK and HDAC6, with IC50s of 16 nM and 1.03 μM, respectively. ALK/HDAC-IN-1 exhibits antitumor activity[1].
Product Specifications
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alk-hdac-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(/N=C1N([C@@H]2CC[C@H](C(NC(C)C)=O)CC2)C3=CC=C(/C=C/C(NO)=O)C=C3N/1)C4=CC=CC=C4
Molecular Formula
C27H31N5O4
Molecular Weight
489.57
References & Citations
[1]Wang KL, et al., Discovery of novel anaplastic lymphoma kinase (ALK) and histone deacetylase (HDAC) dual inhibitors exhibiting antiproliferative activity against non-small cell lung cancer. J Enzyme Inhib Med Chem. 2024 Dec;39 (1) :2318645.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC11; HDAC6; HDAC8
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