3-Deazauridine
3-Deazauridine (NSC 126849) is a uridine analogue. 3-Deazauridine competitively inhibits cytidine triphosphate synthase to inhibit the biosynthesis of cytidine-5'-triphosphate. 3-Deazauridine acts synergistically with several antineoplastic agents, acting as a biological response modifier[1].
Product Specifications
CAS Number
[23205-42-7]
Product Name Alternative
NSC 126849
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/3-deazauridine.html
Concentration
10mM
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(C=C(C=C2)O)=O)O1
Molecular Formula
C10H13NO6
Molecular Weight
243.21
Precautions
H302, H315, H319
References & Citations
[1]Moriconi WJ, et al. 3-Deazauridine (NSC 126849) : an interesting modulator of biochemical response. Invest New Drugs. 1986;4 (1) :67-84.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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