SPAA-52

SPAA-52 is an orally active, competitive and reversible low-molecular-weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC50=4 nM, Ki=1.2 nM) . SPAA-52 can be used in diabete research[1].

Product Specifications

CAS Number

[2837000-75-4]

UNSPSC

12352005

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/spaa-52.html

Purity

97.07

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(O)(NC(NC1=CC(Br)=C(C)C(Br)=C1)=O)=O

Molecular Formula

C8H8Br2N2O4S

Molecular Weight

388.03

References & Citations

[1]He R, et al. Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors. J Med Chem. 2022 Oct 5.