SR2211

SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM.

Product Specifications

CAS Number

[1359164-11-6]

UNSPSC

12352005

Hazard Statement

H301

Target

ROR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/SR2211.html

Purity

99.67

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=C(C2=CC=C(CN3CCN(CC4=CC=NC=C4)CC3)C=C2)C=CC(C(C(F)(F)F)(O)C(F)(F)F)=C1

Molecular Formula

C26H24F7N3O

Molecular Weight

527.48

Precautions

H301

References & Citations

[1]Kumar N, et al. Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem Biol. 2012 Apr 20;7 (4) :672-7.|[2]Song Y, et al. Identification of N-phenyl-2- (N-phenylphenylsulfonamido) acetamides as new RORγ inverse agonists: Virtual screening, structure-based optimization, and biological evaluation. Eur J Med Chem. 2016 Jun 30;116:13-26.