AZD 3043

AZD 3043 (THRX 918661) is a positive allosteric modulator of GABA (A) receptors with sedative and hypnotic activity. AZD 3043 can enhance GABA (A) receptor-mediated chloride currents in vitro and produce hypnotic and electroencephalographic inhibitory effects in vivo. Due to its esterase-dependent metabolic pathway, it has a short duration of action and can be quickly cleared even after long-term infusion, which may have clinical application potential.

Product Specifications

CAS Number

[579494-66-9]

Product Name Alternative

THRX 918661

UNSPSC

12352005

Hazard Statement

H302

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/azd-3043.html

Smiles

CCCOC(CC1=CC=C(OCC(N(CC)CC)=O)C(OCC)=C1)=O

Molecular Formula

C19H29NO5

Molecular Weight

351.44

Precautions

P264-P270-P330-P501

References & Citations

[1]AZD-3043: a novel, metabolically labile sedative-hypnotic agent with rapid and predictable emergence from hypnosis

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

Available Sizes

Curated Selection

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