AZD 3043
AZD 3043 (THRX 918661) is a positive allosteric modulator of GABA (A) receptors with sedative and hypnotic activity. AZD 3043 can enhance GABA (A) receptor-mediated chloride currents in vitro and produce hypnotic and electroencephalographic inhibitory effects in vivo. Due to its esterase-dependent metabolic pathway, it has a short duration of action and can be quickly cleared even after long-term infusion, which may have clinical application potential.
Product Specifications
CAS Number
[579494-66-9]
Product Name Alternative
THRX 918661
UNSPSC
12352005
Hazard Statement
H302
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/azd-3043.html
Smiles
CCCOC(CC1=CC=C(OCC(N(CC)CC)=O)C(OCC)=C1)=O
Molecular Formula
C19H29NO5
Molecular Weight
351.44
Precautions
P264-P270-P330-P501
References & Citations
[1]AZD-3043: a novel, metabolically labile sedative-hypnotic agent with rapid and predictable emergence from hypnosis
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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