L-772405
L-772405 is a selective 5-HT1D receptor agonist with the Ki values of 318, 29 and > 1000 nM aganist guinea pig 5-HT1B receptor, guinea pig 5-HT1D receptor and rat 5-HT rransporter, respectively. L-772405 decreases the potassium-induced outflow of 5-HT with an IC50 value of 240 nM[1].
Product Specifications
CAS Number
[177947-03-4]
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/l-772405.html
Smiles
OC[C@@H](C1=CC=C(C=C1)F)NC(CC2)CCN2CCCC3=CNC4=CC=C(N5C=NN=C5)C=C34
Molecular Formula
C26H31FN6O
Molecular Weight
462.56
References & Citations
[1]Pullar IA, et al. The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig. Eur J Pharmacol. 2004 Jun 16;493 (1-3) :85-93.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor
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