5-Iminodaunorubicin

5-Iminodaunorubicin is a quinone-modified anthracycline that retains antitumor activity[1]. 5-Iminodaunorubicin produces protein-concealed DNA strand breaks in cancer cells[2].

Product Specifications

CAS Number

[72983-78-9]

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/5-iminodaunorubicin.html

Concentration

10mM

Purity

96.26

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC(C=CC=C1C(C2=C(O)C(C[C@@](C(C)=O)(C[C@@H]3O[C@@H]4O[C@H]([C@H]([C@H](C4)N)O)C)O)=C3C(O)=C52)=O)=C1C5=N

Molecular Formula

C27H30N2O9

Molecular Weight

526.54

References & Citations

[1]R A Jensen, et al. Electrocardiographic and transmembrane potential effects of 5-iminodaunorubicin in the rat. Cancer Res. 1984 Sep;44 (9) :4030-9.|[2]L A Zwelling, et al. Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukemia L1210 cells: comparison with adriamycin and 4'- (9-acridinylamino) methanesulfon-m-anisidide. Cancer Res. 1982 Jul;42 (7) :2687-91.