ONO-AE3-208
ONO-AE3-208 is a selective and orally active EP4 receptor antagonist with a Ki of 1.3 nM. ONO-AE3-208 shows less potently affects EP3, FP, and TP receptors (Ki of 30 nM, 790 nM, and 2400 nM, respectively) . ONO-AE3-208 suppresses cell invasion, migration, and metastasis of prostate cancer[1][2].
Product Specifications
CAS Number
402473-54-5
Product Name Alternative
AE 3-208
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/ONO-AE3-208.html
Concentration
10mM
Purity
98.65
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(C(NC(C(C2=C3C=CC=CC3=C(F)C=C2)C)=O)=C1)CCCC(O)=O
Molecular Formula
C24H21FN2O3
Molecular Weight
404.43
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EP; FP; TXA2/TP
Available Sizes
Frequently Asked Questions
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