(S) -Veludacigib

(S) -BAY 2965501 is the left-handed isomer of BAY 2965501 (HY-153343) . BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor. BAY 2965501 induces pERK activation. BAY 2965501 can be used for the research of cancer[1].

Product Specifications

CAS Number

[2732902-09-7]

Product Name Alternative

(S) -BAY 2965501

UNSPSC

12352005

Target

DGK; ERK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-bay-2965501.html

Concentration

10mM

Purity

99.43

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

NC([C@H](C)N(C1=CC=C(C=C1)F)C2=NC(N)=C(C(C3=CC=C(C=C3)OC)=O)S2)=O

Molecular Formula

C20H19FN4O3S

Molecular Weight

414.45

References & Citations

[1]Schubert N, et al. Phosphorylated extracellular signal-regulated kinase (pERK) activation in T effector cells as a target engagement biomarker for the DGK inhibitor BAY2965501 in clinical trials. Cancer Research, 2023, 83 (7_Supplement) : 2116-2116.