Lesinurad
Lesinurad is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 µM, respectively.
Product Specifications
CAS Number
878672-00-5
Product Name Alternative
RDEA594
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
OAT; URAT1
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Lesinurad.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
BrC1=NN=C(SCC(O)=O)N1C2=C3C(C=CC=C3)=C(C4CC4)C=C2
Molecular Formula
C17H14BrN3O2S
Molecular Weight
404.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Shen Z, et al. In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters. Clin Drug Investig. 2016 Jun;36 (6) :443-52|[2]Sattui SE, et al. Treatment of hyperuricemia in gout: current therapeutic options, latest developments and clinical implications. Ther Adv Musculoskelet Dis. 2016 Aug;8 (4) :145-59.|[3]L.Yeh, et al. RDEA594, a potential uric acid lowering agent througn inhibition of uric acid reuptake , shows better pharmacokinetics rhan its prodrug RDEA806. 2008 ACR/ARHP Annual Scientific Meeting, 24-29 October 2008, USA.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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