PCS1055 (dihydrochloride)
PCS1055 dihydrochloride is a potent, selective and competitive muscarinic M4 receptor antagonist with an IC50 of 18.1 nM and a Kd of 5.72 nM. PCS1055 dihydrochloride inhibits radioligand [3H]-NMS binding to the M4 receptor with a Ki of 6.5 nM. PCS1055 dihydrochloride exhibits >100-fold selectivity over M1-, M3-, and M5-receptors and 30-fold selectivity at the M2 receptor. PCS1055 dihydrochloride is also a potent AChE inhibitor with IC50 s of 22 nM and 120 nM for electric eel and human AChE, respectively[1][2].
Product Specifications
CAS Number
[361979-40-0]
UNSPSC
12352005
Target
Cholinesterase (ChE) ; mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pcs1055-dihydrochloride.html
Purity
98.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[H]Cl.[H]Cl.C12=NN=C(NCCC3CCN(CC4=CC=CC=C4)CC3)C=C1CCCC5=CC=CC=C52
Molecular Formula
C27H34Cl2N4
Molecular Weight
485.49
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; mAChR4
Citation 01
Neuron. 2025 Mar 5;113 (5) :670-683.e7.|Mol Cell Endocrinol. 2025 Jan 21:599:112464.
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