Taxifolin

Taxifolin ((+) -Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].

Product Specifications

CAS Number

[480-18-2]

Product Name Alternative

(+) -Dihydroquercetin; (+) -Taxifolin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; TNF Receptor; Tyrosinase

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Taxifolin.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1[C@H](O)[C@@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13

Molecular Formula

C15H12O7

Molecular Weight

304.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Angelis A, et al. Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties. Molecules. 2016 Nov 21;21 (11) :1586.|[2]Yang P, et al. Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MS (n) . Molecules. 2016 Sep 13;21 (9) . pii: E1209.|[3]Lei Ren, et al. Dissecting Efficacy and Metabolic Characteristic Mechanism of Taxifolin on Renal Fibrosis by Multivariate Approach and Ultra-Performance Liquid Chromatography Coupled With Mass Spectrometry-Based Metabolomics Strategy. Front Pharmacol. 2021 Jan 14;11:608511.