DL-Sulforaphane N-acetyl-L-cysteine

DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is an orally active HDAC inhibitor and metabolite of sulforaphane (HY-13755) with longer half-life and better blood-brain barrier permeability. DL-Sulforaphane N-acetyl-L-cysteine activates autophagy-mediated downregulation of α-tubulin expression through the ERK pathway and can be used in cancer research[1][2].

Product Specifications

CAS Number

[334829-66-2]

Product Name Alternative

SFN-NAC

UNSPSC

12352211

Hazard Statement

H315-H319-H335

Target

Apoptosis; Drug Metabolite; HDAC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dl-sulforaphane-n-acetyl-l-cysteine.html

Purity

99.90

Solubility

DMSO : 10 mg/mL (ultrasonic; warming)

Smiles

CS(CCCCNC(SC[C@@H](C(O)=O)NC(C)=O)=S)=O

Molecular Formula

C11H20N2O4S3

Molecular Weight

340.48

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Liu HJ, et al. Sulforaphane-N-Acetyl-Cysteine Induces Autophagy Through Activation of ERK1/2 in U87MG and U373MG Cells. Cell Physiol Biochem. 2018;51 (2) :528-542.|[2]Dashwood R H, et al. Dietary histone deacetylase inhibitors: from cells to mice to man[C]//Seminars in cancer biology. Academic Press, 2007, 17 (5) : 363-369.