(R) -STU104
(R) -STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC50s of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation. (R) -STU104 suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signal pathways through binding with MKK3 and disrupting the TAK1 phosphorylating MKK3. (R) -STU104 can be used for researching ulcerative colitis[1].
Product Specifications
CAS Number
2767124-77-4
UNSPSC
12352005
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-stu104.html
Purity
99.91
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C[C@H](C2=CC=C(OC)C=C2)C3=C1C=C(OC)C=C3OC
Molecular Formula
C18H18O4
Molecular Weight
298.33
References & Citations
[1]Tang ML, et al. Discovery of First-in-Class TAK1-MKK3 Protein-Protein Interaction (PPI) Inhibitor (R) -STU104 for the Treatment of Ulcerative Colitis through Modulating TNF-α Production. J Med Chem. 2022 May 12;65 (9) :6690-6709.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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