A 83-01 (GMP)

A 83-01 (GMP) is A 83-01 (HY-10432) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. A 83-01 is a potent ALK4/5/7 inhibitor[1][2].

Product Specifications

CAS Number

[909910-43-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Anaplastic lymphoma kinase (ALK)

Type

GMP Small Molecules

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/a-83-01-gmp.html

Purity

99.30

Solubility

10 mM in DMSO

Smiles

S=C(N1N=C(C2=NC(C)=CC=C2)C(C3=CC=NC4=CC=CC=C34)=C1)NC5=CC=CC=C5

Molecular Formula

C25H19N5S

Molecular Weight

421.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Guan J, et al. Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature. 2022 May;605 (7909) :325-331.|[2]Liu J, et al. Efficient episomal reprogramming of blood mononuclear cells and differentiation to hepatocytes with functional drug metabolism. Exp Cell Res. 2015 Nov 1;338 (2) :203-13.