Protohypericin

Protohypericin is a compound that can be extracted from Hypericum perforatum. Protohypericin has low photocytotoxicity but can be efficiently photoconverted into Hypericin (HY-N0453) with high phototoxicity under visible light. Protohypericin can be used in cancer research[1][2][3][4].

Product Specifications

CAS Number

[548-03-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Drug Intermediate

Type

Natural Products

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protohypericin.html

Purity

95.15

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(C1=C(O)C=C(C)C=C1C2=C34)C3=C(O)C=C(O)C4=C5C(O)=CC(O)=C6C(C7=C(O)C=C(C)C=C7C2=C65)=O

Molecular Formula

C30H18O8

Molecular Weight

506.46

Precautions

H302, H315, H319

References & Citations

[1]Baugh SF. Simultaneous determination of protopseudohypericin, pseudohypericin, protohypericin, and hypericin without light exposure. J AOAC Int. 2005 Nov-Dec;88 (6) :1607-12.|[2]Liu X, et al. Tumor necrosis targeted radiotherapy of non-small cell lung cancer using radioiodinated protohypericin in a mouse model. Oncotarget. 2015 Sep 22;6 (28) :26400-10.|[3]Kamuhabwa AR, et al. In vitro transport and uptake of protohypericin and hypericin in the Caco-2 model. Int J Pharm. 1999 Oct 15;188 (1) :81-6.|[4]Delaey EM, et al. Photocytotoxicity of protohypericin after photoconversion to hypericin. Planta Med. 1999 Dec;65 (8) :719-22.