Justicidin B

Justicidin B is a potent anticancer lignan and proapoptotic agent. Justicidin B is also a bone resorption inhibitor, and has strong antiviral, fungicidal, antiprotozoal effects. Justicidin B significantly inhibits platelet aggregation[1][2][3].

Product Specifications

CAS Number

[17951-19-8]

Product Name Alternative

Rovamycin

UNSPSC

12352005

Target

Apoptosis; Fungal; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/justicidin-b.html

Purity

99.0

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

O=C1OCC2=CC3=CC(OC)=C(OC)C=C3C(C4=CC=C(OCO5)C5=C4)=C12

Molecular Formula

C21H16O6

Molecular Weight

364.35

References & Citations

[1]Jürg Gertsch, et al. Antifungal, antiprotozoal, cytotoxic and piscicidal properties of Justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum. Planta Med. 2003 May;69 (5) :420-4. |[2]G Momekov, et al. Effect of justicidin B - a potent cytotoxic and pro-apoptotic arylnaphtalene lignan on human breast cancer-derived cell lines. Neoplasma. 2011;58 (4) :320-5. |[3]Iliana Ionkova, et al. Linum narbonense: A new valuable tool for biotechnological production of a potent anticancer lignan Justicidine B. Pharmacogn Mag. 2013 Jan;9 (33) :39-44.