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QX-222 (chloride)

QX-222 chloride, a trimethyl analogue of Lignocaine , is a potent Na+ channel blocker[1][2][3].

Product Specifications

CAS Number

5369-00-6

UNSPSC

12352005

Hazard Statement

H302

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/qx-222-chloride.html

Concentration

10mM

Purity

96.31

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=C(C)C=CC=C1C)C[N+](C)(C)C.[Cl-]

Molecular Formula

C13H21ClN2O

Molecular Weight

256.77

Precautions

H302

References & Citations

[1]A Sunami, et al. A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel. Proc Natl Acad Sci U S A. 2000 Feb 29;97 (5) :2326-31.|[2]Qingmin Chen, et al. Differential blockade of nerve injury-induced thermal and tactile hypersensitivity by systemically administered brain-penetrating and peripherally restricted local anesthetics. J Pain. 2004 Jun;5 (5) :281-9.|[3]J A Flatman, et al. Reversibility of Ia EPSP investigated with intracellularly iontophoresed QX-222. J Neurophysiol. 1982 Aug;48 (2) :419-30.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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