QX-222 (chloride)
QX-222 chloride, a trimethyl analogue of Lignocaine , is a potent Na+ channel blocker[1][2][3].
Product Specifications
CAS Number
5369-00-6
UNSPSC
12352005
Hazard Statement
H302
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/qx-222-chloride.html
Concentration
10mM
Purity
96.31
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=C(C)C=CC=C1C)C[N+](C)(C)C.[Cl-]
Molecular Formula
C13H21ClN2O
Molecular Weight
256.77
Precautions
H302
References & Citations
[1]A Sunami, et al. A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel. Proc Natl Acad Sci U S A. 2000 Feb 29;97 (5) :2326-31.|[2]Qingmin Chen, et al. Differential blockade of nerve injury-induced thermal and tactile hypersensitivity by systemically administered brain-penetrating and peripherally restricted local anesthetics. J Pain. 2004 Jun;5 (5) :281-9.|[3]J A Flatman, et al. Reversibility of Ia EPSP investigated with intracellularly iontophoresed QX-222. J Neurophysiol. 1982 Aug;48 (2) :419-30.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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