PSMα3 (TFA)

PSMα3 TFA is a peptide for manipulating DCs to become tolerogenic for DC vaccination strategies. PSMα3 TFA penetrates and modulates human monocyte-derived DCs by altering the TLR2- or TLR4-induced maturation, inhibiting pro- and anti-inflammatory cytokine production and reducing antigen uptake. PSMα3 TFA is an important toxin released by the most virulent strains of methicillin-resistant Staphylococcus aureus (MRSA) [1][2].

Product Specifications

UNSPSC

12352209

Target

Toll-like Receptor (TLR)

Type

Peptides

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/psmα3-tfa.html

Solubility

H2O

Smiles

NC(C[C@@H](C(O)=O)NC([C@H](CC(N)=O)NC(CNC([C@H](CC(C)C)NC([C@H](CC1=CC=CC=C1)NC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CCCCN)NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](C(C)C)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@H](NC=O)CCSC)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.xOC(C(F)(F)F)=O

Molecular Formula

C130H193F3N28O32S

Molecular Weight

2749.15

References & Citations

[1]Richardson JR, et, al. Staphylococcus aureus PSM Peptides Modulate Human Monocyte-Derived Dendritic Cells to Prime Regulatory T Cells. Front Immunol. 2018 Nov 13;9:2603.|[2]Tayeb-Fligelman E, et, al. The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril. Science. 2017 Feb 24;355 (6327) :831-833.