PSMα3 (TFA)
PSMα3 TFA is a peptide for manipulating DCs to become tolerogenic for DC vaccination strategies. PSMα3 TFA penetrates and modulates human monocyte-derived DCs by altering the TLR2- or TLR4-induced maturation, inhibiting pro- and anti-inflammatory cytokine production and reducing antigen uptake. PSMα3 TFA is an important toxin released by the most virulent strains of methicillin-resistant Staphylococcus aureus (MRSA) [1][2].
Product Specifications
UNSPSC
12352209
Target
Toll-like Receptor (TLR)
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/psmα3-tfa.html
Solubility
H2O
Smiles
NC(C[C@@H](C(O)=O)NC([C@H](CC(N)=O)NC(CNC([C@H](CC(C)C)NC([C@H](CC1=CC=CC=C1)NC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CCCCN)NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](C(C)C)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@H](NC=O)CCSC)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.xOC(C(F)(F)F)=O
Molecular Formula
C130H193F3N28O32S
Molecular Weight
2749.15
References & Citations
[1]Richardson JR, et, al. Staphylococcus aureus PSM Peptides Modulate Human Monocyte-Derived Dendritic Cells to Prime Regulatory T Cells. Front Immunol. 2018 Nov 13;9:2603.|[2]Tayeb-Fligelman E, et, al. The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril. Science. 2017 Feb 24;355 (6327) :831-833.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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