Azido-PEG3-Val-Cit-PAB-PNP

Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG3-Val-Cit-PAB-PNP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[2055047-18-0]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/azido-peg3-val-cit-pab-pnp.html

Purity

99.21

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

O=C(NC(C=C1)=CC=C1COC(OC(C=C2)=CC=C2[N](=O)=O)=O)[C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCN=[N+]=[N-])=O)=O

Molecular Formula

C34H47N9O12

Molecular Weight

773.79

Precautions

H302, H315, H319, H335

References & Citations

[1]Dan N, et al. Antibody-Drug Conjugates for Cancer Therapy: Chemistry to Clinical Implications. Pharmaceuticals (Basel) . 2018 Apr 9;11 (2) . pii: E32.|[2]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.