FD274
FD274 is a highly potent PI3K/mTOR dual inhibitor with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM against PI3Kα/β/γ/δ and mTOR, respectively. FD274 exhibits significant anti-proliferation of AML cell lines (HL-60 and MOLM-16) . FD274 arrests HL-60 cell cycle at G1 phase and increases apoptosis. FD274 demonstrates dose-dependent inhibition of tumor growth in the HL-60 xenograft model. FD274 has the potential for acute myeloid leukemia research[1].
Product Specifications
CAS Number
2641899-38-7
UNSPSC
12352005
Target
Apoptosis; mTOR; PI3K
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fd274.html
Purity
99.45
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
ClC1=NC=C(C2=CN=C(NN=C3C4=CC=NC=C4)C3=C2)C=C1NS(=O)(C5=CC=C(F)C=C5)=O
Molecular Formula
C22H14ClFN6O2S
Molecular Weight
480.90
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTOR; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Available Sizes
Frequently Asked Questions
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