FD274
Product Specifications
UNSPSC Description
FD274 is a highly potent PI3K/mTOR dual inhibitor with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM against PI3Kα/β/γ/δ and mTOR, respectively. FD274 exhibits significant anti-proliferation of AML cell lines (HL-60 and MOLM-16). FD274 demonstrates dose-dependent inhibition of tumor growth in the HL-60 xenograft model. FD274 has the potential for acute myeloid leukemia research[1].
Target Antigen
mTOR; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fd274.html
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
ClC1=NC=C(C2=CN=C(NN=C3C4=CC=NC=C4)C3=C2)C=C1NS(=O)(C5=CC=C(F)C=C5)=O
Molecular Weight
480.90
References & Citations
[1]Chengbin Yang, et al. Discovery of N-(2-chloro-5-(3-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide (FD274) as a highly potent PI3K/mTOR dual inhibitor for the treatment of acute myeloid leukemia. Eur J Med Chem. 2023 Oct 5;258:115543.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155066/FD274-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155066/FD274-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2641899-38-7
Available Sizes
Curated Selection
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