BRD7-IN-1
BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC50s of 4.5 and 1.8 nM, respectively) [1].
Product Specifications
CAS Number
2448414-48-8
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brd7-in-1.html
Purity
99.77
Solubility
DMSO : 30 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
CN1C=C(C2=CC(OC)=C(CN3CCNCC3)C(OC)=C2)C(C=CN=C4)=C4C1=O.Cl.Cl
Molecular Formula
C22H28Cl2N4O3
Molecular Weight
467.39
References & Citations
[1]Zoppi V, et al. Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7. J Med Chem. 2019 Jan 24;62 (2) :699-726.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC682884-100 1x 100 µL
CD6 (Negative Marker of T-regulatory Cells) (C6/2884R), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
TRC-M525630-1MG 1 mg
Mono-2-ethyl-5-carboxypentyl Terephthalate (MECPTP)
Sign In for Pricing
View Details 
BNC881863-500 1x 500 µL
Chromogranin A / CHGA (Neuroendocrine Marker) (rCHGA/777), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details