Azido-PEG2-CH2COOH (CHA)

Azido-PEG2-CH2COOH (CHA) is a azido-modified PEG2 acid, can be used as a click chemistry reagent[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[2098500-94-6]

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

ADC Linker

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/azido-peg2-ch2cooh-cha.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

[N-]=[N+]=NCCOCCOCC(O)=O.NC1CCCCC1

Molecular Formula

C12H24N4O4

Molecular Weight

288.34

Precautions

H315, H319, H335

References & Citations

[1]Lai TH, et al. Long-Term Retarded Release for the Proteasome Inhibitor Bortezomib through Temperature-Sensitive Dendritic Glycopolymers as Drug Delivery System from Calcium Phosphate Bone Cement. Macromol Rapid Commun. 2021 Jul;42 (13) :e2100083.