OAC1

OAC1 is a potent Oct4 activator. OAC1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. OAC1 activates OCT4 through upregulation of HOXB4 expression. OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and TET1. OAC1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time[1][2].

Product Specifications

CAS Number

[300586-90-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Oct3/4; TET Protein

Type

Reference compound

Related Pathways

Epigenetics; Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/OAC1.html

Purity

99.85

Solubility

DMSO : ≥ 40 mg/mL

Smiles

O=C(NC1=CC2=C(NC=C2)C=N1)C3=CC=CC=C3

Molecular Formula

C14H11N3O

Molecular Weight

237.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Li W, et, al. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc Natl Acad Sci U S A. 2012 Dec 18;109 (51) :20853-8.|[2]Huang X, et, al. Activation of OCT4 enhances ex vivo expansion of human cord blood hematopoietic stem and progenitor cells by regulating HOXB4 expression. Leukemia. 2016 Jan;30 (1) :144-53.