JNK-IN-8
JNK-IN-8 (JNK Inhibitor XVI) is a potent JNK inhibitor with IC50s of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively[1].
Product Specifications
CAS Number
1410880-22-6
Product Name Alternative
JNK Inhibitor XVI
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/JNK-IN-8.html
Purity
99.67
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC1=CC(NC(C2=CC=CC(NC(/C=C/CN(C)C)=O)=C2)=O)=CC=C1NC3=NC=CC(C4=CN=CC=C4)=N3
Molecular Formula
C29H29N7O2
Molecular Weight
507.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang T, et al. 
 Discovery of potent and selective covalent inhibitors of JNK.
 Chem Biol. 2012 Jan 27;19 (1) :140-54.|[2]Liu Q, et al. Developing irreversible inhibitors of the protein kinase cysteinome. Chem Biol. 2013 Feb 21;20 (2) :146-59.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JNK1; JNK2; JNK3
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC472853-100 1x 100 µL
CD54 / ICAM-1 (15.2), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC681786-500 1x 500 µL
P63 (Squamous, Basal and Myoepithelial Cell Marker) (TP63/1786), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC741132-100 1x 100 µL
CD45RB (PTPRC/1132), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC882408-500 1x 500 µL
CD14 (Monocyte / Macrophage Marker) (LPSR/2408), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC942961-500 1x 500 µL
C1QB / Complement C1q B-Chain (C1QB/2961), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details