JNK-IN-8
JNK-IN-8 (JNK Inhibitor XVI) is a potent JNK inhibitor with IC50s of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively[1].
Product Specifications
CAS Number
[1410880-22-6]
Product Name Alternative
JNK Inhibitor XVI
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/JNK-IN-8.html
Purity
99.67
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC1=CC(NC(C2=CC=CC(NC(/C=C/CN(C)C)=O)=C2)=O)=CC=C1NC3=NC=CC(C4=CN=CC=C4)=N3
Molecular Formula
C29H29N7O2
Molecular Weight
507.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang T, et al. 
 Discovery of potent and selective covalent inhibitors of JNK.
 Chem Biol. 2012 Jan 27;19 (1) :140-54.|[2]Liu Q, et al. Developing irreversible inhibitors of the protein kinase cysteinome. Chem Biol. 2013 Feb 21;20 (2) :146-59.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JNK1; JNK2; JNK3
Available Sizes
Curated Selection
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