SIRT2-IN-9
SIRT2-IN-9 (compound 12) is a selective inhibitor of SRIT2 with an IC50 value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breast cancer cells. SIRT2-IN-9 can be used for the research of cancer[1].
Product Specifications
CAS Number
[522650-91-5]
UNSPSC
12352005
Hazard Statement
H315-H319
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sirt2-in-9.html
Purity
99.45
Solubility
DMSO : 4.46 mg/mL (ultrasonic; warming; heat to 70°C)
Smiles
O=C(NC1=NC(CCCC2)=C2S1)CSC3=NN=C4C(N(CCC)C5=C4C=CC=C5)=N3
Molecular Formula
C21H22N6OS2
Molecular Weight
438.57
Precautions
P264-P280-P302+P352-P305+P351+P338-P362+P364
References & Citations
[1]Yang SY, Li LL. The purposes of 5H- [1,2,4] triazine [5,6-b] indole derivatives of 3 substitutions. CN108309982A. 2017.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT1; SIRT2; SIRT3
Available Sizes
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