F16

F16 is a potent growth inhibitor of the neu-overexpressing cells and also selectively inhibits proliferation of mammary epithelial as well as a variety of mouse mammary tumor and human breast cancer cell lines. F16 is a mitochondriotoxic compound, and triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell[1][2].

Product Specifications

CAS Number

[36098-33-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/F16.html

Purity

99.94

Solubility

DMSO : ≥ 31 mg/mL|Ethanol : 1 mg/mL (ultrasonic)

Smiles

C[N+]1=CC=C(/C=C/C2=CNC3=C2C=CC=C3)C=C1.[I-]

Molecular Formula

C16H15IN2

Molecular Weight

362.21

Precautions

H302, H315, H319

References & Citations

[1]Fantin VR et al. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell. 2002 Jul;2 (1) :29-42.|[2]Fantin VR et al. F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell. Cancer Res. 2004 Jan 1;64 (1) :329-36.