PBA-1106

PBA-1106 is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1106 increases the autophagic flux of Ub-conjugated aggregates[1].

Product Specifications

CAS Number

[2410081-55-7]

UNSPSC

12352005

Target

Autophagy; AUTOTACs

Type

Reference compound

Related Pathways

Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pba-1106.html

Smiles

O[C@H](CNCCOCCOCCOCCNC(CCCC1=CC=CC=C1)=O)COC2=CC(OCC3=CC=CC=C3)=C(OCC4=CC=CC=C4)C=C2

Molecular Formula

C41H52N2O8

Molecular Weight

700.86

References & Citations

[1]Chang Hoon Ji, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13 (1) :904.