Teixobactin
Teixobactin is a potent antibiotic. Teixobactin shows antibacterial activity for gram-negative bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II and lipid III[1][2][3].
Product Specifications
CAS Number
1613225-53-8
UNSPSC
12352209
Target
Antibiotic; Bacterial
Type
Peptides
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/teixobactin.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@](C(O[C@H]([C@H](C(N[C@H](C(N1)=O)C)=O)NC([C@H](CO)NC([C@H]([C@@H](C)CC)NC([C@@H]([C@@H](C)CC)NC([C@@H](CCC(N)=O)NC([C@H](CO)NC([C@H]([C@@H](C)CC)NC([C@H](NC)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)C)=O)([H])[C@@H](C)CC)[C@@H]1C[C@H]3CN=C(N3)N
Molecular Formula
C58H95N15O15
Molecular Weight
1242.47
References & Citations
[1]Piddock LJ. Teixobactin, the first of a new class of antibiotics discovered by iChip technology? J Antimicrob Chemother. 2015 Oct;70 (10) :2679-80.|[2]Parmar A, et al. Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding. Chem Sci. 2017 Dec 1;8 (12) :8183-8192.|[3]Ling LL, et al. A new antibiotic kills pathogens without detectable resistance. Nature. 2015 Jan 22;517 (7535) :455-9.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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