Teixobactin

Teixobactin is a potent antibiotic. Teixobactin shows antibacterial activity for gram-negative bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II and lipid III[1][2][3].

Product Specifications

CAS Number

[1613225-53-8]

UNSPSC

12352209

Target

Antibiotic; Bacterial

Type

Peptides

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/teixobactin.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@](C(O[C@H]([C@H](C(N[C@H](C(N1)=O)C)=O)NC([C@H](CO)NC([C@H]([C@@H](C)CC)NC([C@@H]([C@@H](C)CC)NC([C@@H](CCC(N)=O)NC([C@H](CO)NC([C@H]([C@@H](C)CC)NC([C@H](NC)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)C)=O)([H])[C@@H](C)CC)[C@@H]1C[C@H]3CN=C(N3)N

Molecular Formula

C58H95N15O15

Molecular Weight

1242.47

References & Citations

[1]Piddock LJ. Teixobactin, the first of a new class of antibiotics discovered by iChip technology? J Antimicrob Chemother. 2015 Oct;70 (10) :2679-80.|[2]Parmar A, et al. Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding. Chem Sci. 2017 Dec 1;8 (12) :8183-8192.|[3]Ling LL, et al. A new antibiotic kills pathogens without detectable resistance. Nature. 2015 Jan 22;517 (7535) :455-9.