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Flumexadol

Flumexadol is a selective and affinity 5-HT2C receptor agonist with a Ki of 25 nM for the (+) -enantiomer of Flumexadol, and is 40-fold selective over the 5-HT2A receptor. Flumexadol is an orally active non-narcotic analgesic[1][2].

Product Specifications

CAS Number

30914-89-7

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/flumexadol.html

Purity

99.86

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

FC(C1=CC(C2CNCCO2)=CC=C1)(F)F

Molecular Formula

C11H12F3NO

Molecular Weight

231.22

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Hache J, et al. The pharmacology of 1841 CERM, a new analgesic. Arzneimittelforschung. 1978;28 (4) :642-5.|[2]Nilsson BM. 5-Hydroxytryptamine 2C (5-HT2C) receptor agonists as potential antiobesity agents. J Med Chem. 2006 Jul 13;49 (14) :4023-34.|[3]Kucharczyk N, et al. Metabolites of 2- (3-trifluoromethylphenyl) tetrahydro-1,4-oxazine (CERM) 1841) in rats and dogs. Xenobiotica. 1979 Nov;9 (11) :703-11.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT2 Receptor; α-1 microglobulin

Available Sizes

Frequently Asked Questions

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