RSS0680

RSS0680 is a small noncoding RNA (sRNA) targeting the mRNA ribosome binding site (RBS) and a PROTAC with protein kinase degradation activity (Pink: FLT3-IN-17 (HY-148070) ; Black: Linker (HY-W041970) ; Blue: E3 ligase Ligand (HY-112078) ) . RSS0680 competitively binds to RBS through the conserved CCUCCUCCC anti-Shine-Dalgarno (aSD) sequence and inhibits the translation initiation of target genes. RSS0680 can interact with the DUF1127 protein CcaF1, regulate its own stability and participate in bacterial oxidative stress defense, enhancing the host's resistance to heat shock and oxidative damage by affecting pathways such as C1 metabolism and pyruvate dehydrogenase complex. RSS0680 degrades AAK1, CDK1, CDK16, CDK2, CDK4, CDK6, EIF2AK4, GAK, LATSl, LIMK2, MAPK6, MAPKAPK5, MARK2, MARK4, MKNK2, NEK9, RPS6KB1, SIK2, SNRK, STK17A, STK17B, STK35, and WEEl. RSS0680 can be used to study diseases or disorders mediated by aberrant kinase activity and regulatory mechanisms of noncoding RNAs in α-proteobacteria[1][2].

Product Specifications

CAS Number

[2769753-48-0]

UNSPSC

12352005

Target

AAK1; CDK; Cyclin G-associated Kinase (GAK) ; LIM Kinase (LIMK) ; PROTACs; Salt-inducible Kinase (SIK) ; Wee1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Neuronal Signaling; PROTAC

Applications

COVID-19-anti-virus

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/rss0680.html

Purity

99.85

Solubility

DMSO : 200 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CS(NC1=CC=CC(C2=CSC3=CN=C(N=C23)NC4=CC=C(N5CCN(CC5)CCCCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(N[C@H](C7=CC=C(C8=C(N=CS8)C)C=C7)C)=O)=O)=O)C=C4)=C1)(=O)=O

Molecular Formula

C52H64N10O6S3

Molecular Weight

1021.32

References & Citations

[1]Reinkensmeier J, et al. Thermodynamic matchers for the construction of the cuckoo RNA family. RNA Biol. 2015;12 (2) :197-207|[2]Grützner J, et al. The small DUF1127 protein CcaF1 from Rhodobacter sphaeroides is an RNA-binding protein involved in sRNA maturation and RNA turnover. Nucleic Acids Res. 2021 Apr 6;49 (6) :3003-3019.