RSS0680
Product Specifications
UNSPSC Description
RSS0680 (Example 22) is a bifunctional compound targeted protein degradation of kinases. RSS0680 degrades AAK1, CDK1, CDK16, CDK2, CDK4, CDK6, EIF2AK4, GAK, LATSl, LIMK2, MAPK6, MAPKAPK5, MARK2, MARK4, MKNK2, NEK9, RPS6KB1, SIK2, SNRK, STK17A, STK17B, STK35, and WEEl. RSS0680 can be used for research of disease or disorder mediated by aberrant kinase activity[1].
Target Antigen
AAK1; CDK; Cyclin G-associated Kinase (GAK); LIM Kinase (LIMK); PROTACs; Salt-inducible Kinase (SIK); Wee1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Immunology/Inflammation;Neuronal Signaling;PROTAC
Applications
COVID-19-anti-virus
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/rss0680.html
Solubility
DMSO : 200 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CS(NC1=CC=CC(C2=CSC3=CN=C(N=C23)NC4=CC=C(N5CCN(CC5)CCCCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(N[C@H](C7=CC=C(C8=C(N=CS8)C)C=C7)C)=O)=O)=O)C=C4)=C1)(=O)=O
Molecular Weight
1021.32
References & Citations
[1]Gray Nathanael S, et al. Bifunctional compounds for targeted protein degradation of kinases: World Intellectual Property Organization, WO2022093742[P]. 2022-05-05.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-148062/RSS0680-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-148062/RSS0680-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2769753-48-0
Available Sizes
Curated Selection
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