IBT6A
IBT6A is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct[1]. Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM[2].
Product Specifications
CAS Number
1022150-12-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Btk-inhibitor-1-R-enantiomer.html
Concentration
10mM
Purity
99.59
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=C2C(N([C@H]3CNCCC3)N=C2C4=CC=C(OC5=CC=CC=C5)C=C4)=NC=N1
Molecular Formula
C22H22N6O
Molecular Weight
386.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Liu N, et al. Direct and two-step bioorthogonal probes for Bruton's tyrosine kinase based on ibrutinib: a comparative study. Org Biomol Chem. 2015 May 14;13 (18) :5147-57.|[2]Somana Siva Prasad, et al. A QUALITY BY DESIGN APPROACH FOR DEVELOPMENT OF SIMPLE AND ROBUST REVERSED PHASE STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF IBRUTINIB AND ITS IMPURITIES.|[3]Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107 (29) :13075-80.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC401917-500 1x 500 µL
Chromogranin A / CHGA (Neuroendocrine Marker) (rCHGA/798), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
![ICAM3 Mouse Monoclonal Antibody [Clone ID: B-R1]](https://cdn.genprice.uk/products/937/68dd189d061270361e8fd212/imageurl/am31186pu-n.webp)
AM31186PU-N 2 mL (200 Tests)
ICAM3 Mouse Monoclonal Antibody [Clone ID: B-R1]
Sign In for Pricing
View Details 
BNCB2618-100 1x 100 µL
Cadherin 17 / LI Cadherin (Liver-Intestine Marker) (CDH17/2618), Biotin conjugate, 0.1mg/mL
Sign In for Pricing
View Details