Pomalidomide-C7-NH2 (hydrochloride)

Pomalidomide-C7-NH2 (Pomalidomide 4'-alkylC7-amine) hydrochloride is an E3 ligase ligand-linker conjugate. Pomalidomide-C7-NH2 hydrochloride can be used for the synthesis of PROTAC[1][2].

Product Specifications

CAS Number

[2446474-05-9]

Product Name Alternative

Pomalidomide 4'-alkylC7-amine (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pomalidomide-c7-nh2-hydrochloride.html

Purity

98.98

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCCCCCCN)=O.[H]Cl

Molecular Formula

C20H27ClN4O4

Molecular Weight

422.91

Precautions

H302, H315, H319

References & Citations

[1]Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62 (2) :448-466.|[2]Si Woo Choi, et al. Hmg-coa reductase degradation inducing compound. Patent, WO2021201577A1.