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Anti-Hu CD173 PE

CD173 (blood group antigen H2) is a fucosylated saccharide (Fuc-alpha-1-2-Gal-beta-1-4-GlcNAc-beta) generated by beta-D-galactoside 2-alpha-L-fucosyltransferase (FUT1) . CD173 belongs to markers of early hematopoiesis; it is expressed mainly on CD34-positive hematopoietic progenitor cells. CD173 is a precursor structure of CD174 (Lewis Y) and is also structurally related to CD15 (Lewis X) . On endothelial cells CD173 and CD174 are concentrated on pseudopodial extensions responsible for initial contacts between endothelial cells.

Product Specifications

Certification

RUO

Immunogen

Human thrombocytes

Target Antigen

CD173

Clone

MEM-195

Applications

FC (QC tested)

Format

PE

Buffer

Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Other References

*Moehler TM, Sauer S, Witzel M, Andrulis M, Garcia-Vallejo JJ, Grobholz R, Willhauck-Fleckenstein M, Greiner A, Goldschmidt H, Schwartz-Albiez R: Involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis (y) (CD174) in first endothelial cell-cell contacts during angiogenesis. J Cell Physiol. 2008 Apr;215 (1) :27-36., URL: https://www.ncbi.nlm.nih.gov/pubmed/18205178?itool, *Cao Y, Merling A, Karsten U, Schwartz-Albiez R: The fucosylated histo-blood group antigens H type 2 (blood group O, CD173) and Lewis Y (CD174) are expressed on CD34+ hematopoietic progenitors but absent on mature lymphocytes. Glycobiology. 2001 Aug;11 (8) :677-83., URL: https://www.ncbi.nlm.nih.gov/pubmed/11479278?itool

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The antibody MEM-195 reacts with CD173 (H2), an extracellular saccharide antigen expressed mainly during early hematopoiesis; it is also expressed on endothelial cells.

Applications Notes

6

Species

Human

CAS Number

9007-83-4

Isotype

Mouse IgM

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