What is the catalog number for BPTES?

The catalog number for BPTES is HY-12683.

What sizes are available for BPTES?

BPTES is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg.

How many pack sizes does BPTES come in?

BPTES is available in 7 different pack sizes.

BPTES is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures BPTES?

BPTES is manufactured by QuantiMol.

What is the estimated delivery time for BPTES?

Estimated delivery time for BPTES is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for BPTES?

The safety data sheet for BPTES is available here: http://file.medchemexpress.com/batch_PDF/HY-12683/BPTES-SDS-MedChemExpress.pdf.

BPTES

BPTES is an allosteric and selective glutaminase inhibitor with an IC50 of 0.16 μM.

Product Specifications

CAS Number

314045-39-1

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Glutaminase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BPTES.html

Purity

98.75

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(NC1=NN=C(CCSCCC2=NN=C(NC(CC3=CC=CC=C3)=O)S2)S1)CC4=CC=CC=C4

Molecular Formula

C24H24N6O2S3

Molecular Weight

524.68

Precautions

H315, H319, H335

References & Citations

[1]Elgogary A, et al. Combination therapy with BPTES nanoparticles and targets the metabolic heterogeneity of pancreatic cancer. Proc Natl Acad Sci U S A. 2016 Sep 6;113 (36) :E5328-36.|[2]Meghan J. Seltzer, et al. Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res. 2010 Nov 15; 70 (22) : 8981-8987.|[3]Lee JS, et al. Glutaminase 1 inhibition reduces thymidine synthesis in NSCLC. Biochem Biophys Res Commun. 2016 Aug 26;477 (3) :374-82|[4]Lee JS, et al. Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC. Cell Death Dis. 2016 Dec 8;7 (12) :e2511.