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Lepunafusp alfa

Lepunafusp alfa (JR-171) is a BBB-penetrable fusion protein consisting of J-Brain Cargo and IDUA (a lysosomal enzyme, α-L-iduronidase) . Lepunafusp alfa can reduce concentration of heparan sulfate (HS) and dermatan sulfate (DS) . Lepunafusp alfa can be used for research of mucopolysaccharidosis type I[1][2].

Product Specifications

CAS Number

[2396411-71-3]

Product Name Alternative

JR-171

UNSPSC

12352203

Target

Transferrin Receptor

Type

Inhibitory Antibodies

Related Pathways

Apoptosis

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lepunafusp-alfa.html

Solubility

10 mM in DMSO

Smiles

[Lepunafuspalfa]

References & Citations

[1]Jeong GU, et al. Non-clinical evaluation of a blood-brain barrier-penetrating enzyme for the treatment of mucopolysaccharidosis type I. Molecular Genetics and Metabolism. 2019. 126 (2), S83-S84.

Shipping Conditions

Room temperature

Scientific Category

Inhibitory Antibodies

Clinical Information

Phase 2

Curated Selection

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