Human IL-22 R alpha 1 Protein, Fc Tag
Human IL-22 R alpha 1, Fc Tag (IL1-H5258) is expressed from human 293 cells (HEK293) . It contains AA His 16 - Thr 228 (Accession # Q8N6P7-1) .
Product Specifications
Background
Interleukin-22 receptor subunit alpha-1 (IL22RA1) is a component of the receptor for IL20, IL22 and IL24.Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
Specifications
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.9 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
Q8N6P7-1
Expression Region
His 16 - Thr 228
Host
HEK293
Target
IL-22 R alpha 1
Conjugation
Unconjugated
Tag
C-Fc
Source
Human
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
95%
Bioactivity
Immobilized Human IL-22, His Tag (Cat. No. IL2-H524a) at 5 μg/mL (100 μL/well) can bind Human IL-22 R alpha 1, Fc Tag (Cat. No. IL1-H5258) with a linear range of 2-78 ng/mL (QC tested).
Format
Powder
Buffer
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
50.9 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
1mg*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/IL1-H5258.pdf
Species
Human
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