Fostriecin (sodium)

Fostriecin (sodium) (compound 1, CI-920) is an antibiotic with a cytotoxic activity. Fostriecin (sodium) is also an inhibitor of protein phosphatase including PP4 (IC50= 3 nM) and PP2 (IC50=1.5 nM) [1].

Product Specifications

CAS Number

[87860-39-7]

Product Name Alternative

PD 110161 (sodium) ; CL 1565A (sodium) ; CI-920 (sodium)

UNSPSC

12352211

Target

Antibiotic; Phosphatase

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fostriecin-sodium.html

Purity

95.00

Solubility

10 mM in DMSO

Smiles

O=C(C=CC1)O[C@H]1/C=C/[C@@](C)(O)[C@H](OP(O)(O[Na])=O)C[C@@H](O)/C=C\C=C/C=C/CO

Molecular Formula

C19H26NaO9P

Molecular Weight

452.37

References & Citations

[1]Keisuke Mak, et al. Catalyst-controlled asymmetric synthesis of fostriecin and 8-epi-fostriecin. J Am Chem Soc. 2005, 127, 48.|[2]C J Hastie, et al. Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters. FEBS Lett. 1998, 431, 3.