Pyridostatin (TFA)

Pyridostatin (RR82) TFA is a G-quadruplex DNA stabilizing agent (Kd=490 nM) and can target DNA and RNA G4s in cells. Pyridostatin TFA promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin TFA targets the proto-oncogene Src. Pyridostatin TFA reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells[1][2][3].

Product Specifications

CAS Number

[1472611-44-1]

Product Name Alternative

RR82 (TFA)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

G-quadruplex

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pyridostatin-tfa.html

Purity

99.54

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=NC(C(NC2=NC3=CC=CC=C3C(OCCN)=C2)=O)=CC(OCCN)=C1)NC4=NC5=CC=CC=C5C(OCCN)=C4.O=C(O)C(F)(F)F

Molecular Formula

C33H33F3N8O7

Molecular Weight

710.66

Precautions

H302, H315, H319, H335

References & Citations

[1]Rodriguez R, et al. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol. 2012;8 (3) :301-310. Published 2012 Feb 5.|[2]Koirala D, et al. A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat Chem. 2011;3 (10) :782-787. Published 2011 Aug 28.|[3]Moruno-Manchon JF, et al. The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons. Aging (Albany NY) . 2017;9 (9) :1957-1970.|[4]Zhang X, et al. Chemical profiling of DNA G-quadruplex-interacting proteins in live cells. Nat Chem. 2021 Jul;13 (7) :626-633.